Key result
Among stroke patients deemed too good for intravenous thrombolysis, 32% experienced a poor outcome (not discharged home), independently predicted by age, initial NIHSS, and infarct location.
Population
380 acute stroke patients presenting ≤4.5 hours who did not receive intravenous tissue-type plasminogen…
Design
Cohort
Follow-up
Until hospital discharge
Authors
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Caution warranted when labeling mild strokes "too good to treat"; leaves open whether age-, NIHSS-, and location-based criteria warrant prospective validation.
Observational (n=380)
No
A significant proportion of stroke patients deemed 'too good to treat' with IV tPA experience poor outcomes, suggesting the need to re-evaluate treatment criteria based on age, NIHSS, and infarct location.
Ali et al. (2016) conducted an observational in Stroke (n=380). Baseline clinical and imaging features (age, initial NIHSS, infarct location) was evaluated on Poor outcome (defined as not being discharged to home). Among stroke patients deemed too good for intravenous thrombolysis, 32% experienced a poor outcome (not discharged home), independently predicted by age, initial NIHSS, and infarct location.
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