Key result
In Langendorff-perfused rat hearts, microspheres affect vascular resistance in a flow reserve-dependent manner, causing large decreases in perfusion pressure at low numbers when flow reserve is present.
Population
Langendorff-perfused rat hearts
Comparison
Seven successive injections of 0.1 ml of 0.05%… vs Injections of saline or 0.05% polysorbate 20 alone
Design
Preclinical
Authors
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May confound coronary resistance measurements in perfused heart models; leaves open validation of microsphere techniques for flow studies.
The microsphere technique itself affects cardiac vascular resistance in a flow reserve-dependent manner, which may confound hemodynamic measurements in experimental models.
Zuurbier et al. (2003) studied Langendorff-perfused rat heart. Microspheres vs. Saline or 0.05% Tween 20 was evaluated on Perfusion pressure and mitochondrial energy status (NADH). In Langendorff-perfused rat hearts, microspheres affect vascular resistance in a flow reserve-dependent manner, causing large decreases in perfusion pressure at low numbers when flow reserve is present.