This review highlights the neurogenic actions of angiotensin II on brain cardiovascular centers and its role in regulating central adrenoreceptor activity, pituitary function, and hydromineral metabolism.
Review synthesizes central angiotensin II mechanisms; leaves open therapeutic translation in hypertension.
It has become increasingly evident that blood-borne angiotensin II has major effects upon brain cardiovascular centers. With the discovery of an angiotensin I-forming enzyme or isoenzymes in the central nervous system of mammals, alternative concepts have emerged regarding the role of this peptide in the regulation of central adrenoreceptor activity, pituitary function, and hydromineral metabolism. These concepts are reviewed, and a framework for future research is suggested by the author.
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Carlos M. Ferrario (1983) studied this question.
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