Population
Yeast (S. cerevisiae) extracts
Design
Preclinical
Authors
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Refines yeast spliceosome assembly models; leaves open validation in mammalian systems and disease relevance.
Demonstrates that U5 snRNP is essential for late stages of spliceosome assembly and pre-mRNA splicing in yeast.
Séraphin et al. (1991) studied this question.
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