Why the study?
Is increased GGT activity associated with impaired antioxidant system and increased aortic stiffness in patients with newly diagnosed essential hypertension?
Is increased GGT activity associated with impaired antioxidant system and increased aortic stiffness in patients with newly diagnosed essential hypertension?
Increased GGT activity is independently associated with increased aortic stiffness and impaired antioxidant capacity in patients with newly diagnosed essential hypertension.
Supports GGT as marker of stiffness and oxidative stress in new hypertension; leaves open causal role and need for prospective trials.
BACKGROUND: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). METHODS: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. RESULTS: PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = -0.343, P < 0.001) as well as hs-CRP (β = 0.334, P < 0.001). CONCLUSION: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Gözükara et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: