Population
Male spontaneously hypertensive rats (SHR)
Comparison
Streptozotocin-induced diabetes vs Control spontaneously hypertensive rats (SHR)
Design
Preclinical
Follow-up
5 days after STZ
Authors
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Highlights autonomic impairment in diabetic hypertensive rat models; hypothesis-generating with no clinical implications yet.
In spontaneously hypertensive rats, STZ-induced diabetes impairs peripheral cardiovascular sympathetic modulation and baroreceptor function while reducing blood pressure.
Farah et al. (2007) studied this question.
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