Why the study?
In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of DOACs are present, prompting investigation into whether urine DOAC dipstick testing can exclude plasma concentrations ≥30 ng/mL.
Does DOAC Dipstick testing in urine reliably exclude clinically relevant DOAC plasma concentrations (≥30 ng/mL) in patients treated with DOACs?
Population
128 consecutive patients treated with oral direct factor Xa inhibitors or direct thrombin inhibitors
Comparison
Urine DOAC Dipstick testing vs plasma chromogenic substrate assays
Design
Prospective single-center cohort study
Authors
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May support point-of-care exclusion of relevant DOAC levels; leaves open prospective validation before routine use.
Does DOAC Dipstick testing in urine reliably exclude clinically relevant DOAC plasma concentrations (≥30 ng/mL) in patients treated with DOACs?
DOAC Dipstick testing in urine can reliably exclude clinically relevant DOAC plasma concentrations (≥30 ng/mL) with 100% negative predictive value.
Margetić et al. (2022) studied this question.
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