Key result
The DOAC Dipstick detected factor Xa inhibitor plasma levels ≥30 ng/mL with 97.4% sensitivity and 68.6% specificity, and dabigatran levels with 100% sensitivity and 97.9% specificity.
Why the study?
An accurate point-of-care test for detecting effective anticoagulation by direct oral anticoagulants in emergencies remains an unmet need.
Does the DOAC Dipstick accurately detect DOAC plasma levels ≥30 ng/mL in adults on DOAC treatment presenting to an emergency department?
Population
265 adults on DOAC treatment presenting to an emergency department
Comparison
DOAC Dipstick urine test vs liquid chromatography coupled with tandem-mass spectrometry reference standard
Design
Prospective single-center cohort-type cross-sectional diagnostic accuracy study
Authors
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May aid emergency DOAC detection; leaves open prospective validation before clinical use.
Cross-Sectional (n=265)
Blinded to reference standard and clinical data
No
Does the DOAC Dipstick accurately detect DOAC plasma levels ≥30 ng/mL in adults on DOAC treatment presenting to an emergency department?
Effect estimate: Sensitivity 97.4% (95% CI 94.1-99.2)
The DOAC Dipstick is a highly sensitive point-of-care test for detecting relevant DOAC exposure in emergency department patients, though specificity for factor Xa inhibitors is moderate.
Merrelaar et al. (2022) conducted a cross-sectional in DOAC exposure in emergency department patients (n=265). DOAC Dipstick vs. Liquid chromatography coupled with tandem-mass spectrometry (LC-MS/MS) was evaluated on Sensitivity to detect ≥30 ng/mL factor Xa inhibitor plasma levels (Sensitivity 97.4%, 95% CI 94.1-99.2). The DOAC Dipstick detected factor Xa inhibitor plasma levels ≥30 ng/mL with 97.4% sensitivity and 68.6% specificity, and dabigatran levels with 100% sensitivity and 97.9% specificity.
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