What is the clinical evidence from this study?

Study design: Observational. Population: acute stroke and transient ischemic attack (n=66). Intervention: DOAC Dipstick point-of-care testing. Primary outcome: success rate of evaluable pad results and time to results after urine sampling.

What does this research mean for the field?

The DOAC Dipstick point-of-care test rapidly and accurately identifies the presence or absence of direct oral anticoagulants in patients with acute stroke and transient ischemic attack, correctly identifying status in 100% of the tested cohort with a median time to visual result of 20 minutes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research evaluates the feasibility of using the DOAC Dipstick for detecting direct oral anticoagulants in patients with acute stroke and TIA.

June 11, 2026Cerebrovascular Diseases ExtraOpen Access

Feasibility of DOAC Dipstick point-of-care testing in patients with acute stroke and transient ischemic attack

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Key result

DOAC Dipstick point-of-care test correctly identifies DOAC presence with ~100% accuracy.

n=66

Why the study?

In patients with acute stroke, plasma DOAC concentrations must be known for treatment decisions, prompting evaluation of the DOAC Dipstick point-of-care urine test.

Does DOAC Dipstick point-of-care testing rapidly and reliably detect DOACs in patients with acute stroke and TIA?

Population

66 patients with acute stroke and TIA fulfilling inclusion criteria

Comparison

DOAC Dipstick testing in patients with vs without DOAC intake

Design

Feasibility study

Authors

MZMaximilian Ziegler KSKristina Szabo CHCarolin HoyerHeidelberg University

Discussion

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Implication

Supports point-of-care DOAC detection in acute stroke/TIA; leaves open effects on management and outcomes.

Key Points

This research evaluates the feasibility of using the DOAC Dipstick for detecting direct oral anticoagulants in patients with acute stroke and TIA.
Urine samples obtained from patients within 8 hours of hospitalization, with prior DOAC intake noted.
The DOAC Dipstick was used to test urine samples for DOAC presence within a short timeframe.
Results were analyzed visually and with a semi-automated reader.
66 patients completed the study, with a median time of 20 minutes to visual results and 24 minutes to reader results.
All urine samples from patients with previous DOAC intake (n=26) tested positive for DOACs, while those without (n=39) tested negative.
Complications included minor delays and issues with test strip evaluability affecting a small number of patients.

Study Design

Type

Observational (n=66)

Structured PICO

Does DOAC Dipstick point-of-care testing rapidly and reliably detect DOACs in patients with acute stroke and TIA?

Population

66 patients with acute stroke and TIA (mean age 73 years, 39% female) who had urine samples obtained within 8 hours of hospitalisation.

Exposure

DOAC Dipstick point-of-care testing of urine samples obtained within 8 hours after hospitalisation.

Outcome

Success rate of evaluable pad results and time to results after urine sampling.

The DOAC Dipstick is a rapid and reliable point-of-care test for detecting the presence of DOACs in patients presenting with acute stroke or TIA, which may aid in acute treatment decisions.

Cite This Study

Ziegler et al. (2026) conducted an observational in acute stroke and transient ischemic attack (n=66). DOAC Dipstick point-of-care testing was evaluated on success rate of evaluable pad results and time to results after urine sampling. The DOAC Dipstick point-of-care test correctly identified DOAC presence in 26 of 26 patients with prior intake and absence in 39 of 39 without, with a median time to visual result of 20 minutes.

synapsesocial.com/papers/6a2a50b680c8f91e7f39d196 https://doi.org/10.1159/000552560

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Feasibility of DOAC Dipstick point-of-care testing in patients with acute stroke and transient ischemic attack

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Feasibility of DOAC Dipstick point-of-care testing in patients with acute stroke and transient ischemic attack

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider