Key result
Urine DOAC dipsticks detect relevant anticoagulation with 100% accuracy vs blood tests in acute ischemic stroke.
Why the study?
Point-of-care urine testing offers a promising approach to rapidly assess DOAC presence, but its utility needed evaluation in patients with acute ischemic stroke or transient ischemic attack.
Does a urine-based DOAC dipstick test accurately and rapidly detect factor-Xa-inhibitors in acute ischemic stroke patients compared to standard blood-based testing?
Observational (n=44)
Single-blind
No
Does a urine-based DOAC dipstick test accurately and rapidly detect factor-Xa-inhibitors in acute ischemic stroke patients compared to standard blood-based testing?
Effect estimate: 100% sensitivity
A urine-based DOAC dipstick test provides a rapid and highly accurate method for detecting factor-Xa inhibitors in acute ischemic stroke patients, potentially saving critical time for acute treatment decisions.
No takes yet. Share an insight, caveat, or question.
May support rapid urine DOAC testing in acute stroke; leaves open validation in larger prospective cohorts before adoption.
Doeppner et al. (2023) conducted an observational in Acute ischemic stroke or transient ischemic attack (n=44). Urine-based DOAC dipstick test vs. Standard blood-based specific DOAC-level assessment was evaluated on Sensitivity to detect relevant anticoagulatory activity (drug-specific anti-Xa level ≥30 ng/mL) (100% sensitivity). The urine-based DOAC dipstick test demonstrated 100% sensitivity and 100% specificity in identifying relevant anticoagulatory activity compared to standard blood tests in acute ischemic stroke patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: