Key result
The DOAC Dipstick accurately detected DOACs in urine compared with LC-MS/MS, with accuracy noninferior to 95% for factor Xa inhibitors and superior to 97.5% for thrombin inhibitors (all p<0.05).
Why the study?
Rapid determination of DOACs remains a major challenge in emergency medicine and for rapid treatment decisions.
Does the DOAC Dipstick point-of-care urine test accurately detect the presence of direct oral factor Xa or thrombin inhibitors compared to LC-MS/MS in patients on DOAC therapy?
Observational (n=914)
Yes
Does the DOAC Dipstick point-of-care urine test accurately detect the presence of direct oral factor Xa or thrombin inhibitors compared to LC-MS/MS in patients on DOAC therapy?
p-value: p=< 0.05
The DOAC Dipstick is a highly accurate point-of-care urine test for detecting direct oral anticoagulants, which could rapidly inform clinical decision-making in emergency situations.
No takes yet. Share an insight, caveat, or question.
May support bedside screening when history is unavailable; leaves open emergency outcome data and should not yet change practice.
Harenberg et al. (2019) conducted an observational in Presence of direct oral anticoagulants (DOACs) (n=914). DOAC Dipstick pads vs. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was evaluated on Correct positive and negative predictive results (sensitivity, specificity, accuracy, and predictive values) (p=< 0.05). The DOAC Dipstick accurately detected DOACs in urine compared with LC-MS/MS, with accuracy noninferior to 95% for factor Xa inhibitors and superior to 97.5% for thrombin inhibitors (all p<0.05).
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