August 1, 1988Journal of General Virology

Antigenic Variation among 173 Strains of Type 3 Poliovirus Isolated in Finland during the 1984 to 1985 Outbreak

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Population

173 strains of type 3 poliovirus from the 1984 to 1985 Finland outbreak

Design

Preclinical

Authors

AHAnita HuovilainenFinnish Food Authority LKLeena KinnunenUniversity of Essex MFMichael A. J. FergusonBrigham and Women's Hospital

Discussion

Member takes

Implication

Antigenic variation in type 3 poliovirus may affect neutralization; leaves open pathogenetic and epidemiological implications.

Structured PICO

Population

173 strains of type 3 poliovirus (128 clinical isolates from 95 persons and 45 strains from sewage water specimens) from the 1984 to 1985 Finland outbreak

Intervention

Evaluation using five neutralizing monoclonal antibodies (MAbs) directed against an antigenic site on VP1 and partial RNA sequencing

Outcome

Antigenic properties and variation of the poliovirus strainssurrogate

The antigenic sites of type 3 poliovirus vary extensively within a given outbreak and even during replication in a given host, which may have pathogenetic and epidemiological significance.

Cite This Study

Huovilainen et al. (1988) studied this question.

synapsesocial.com/papers/6a8504075d33534bf2de0882 https://doi.org/10.1099/0022-1317-69-8-1941

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