September 15, 2010Physiological GenomicsOpen Access

Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain

View Full Paper

Ask AI

Bookmark

Population

Consomic rat strains derived from a cross between the Fawn Hooded Hypertensive rat and the Brown Norway…

Comparison

Substitution of individual BN chromosomes into… vs FHH genetic background, different salt diets…

Design

Preclinical

Follow-up

3 wk

Authors

MKMary Pat KunertMarquette University MDMelinda R. DwinellMedical College of Wisconsin JLJulian H. LombardMedical College of Wisconsin

Discussion

Member takes

Implication

Vascular reactivity genetics in hypertensive rat models are highly strain- and sex-specific; leaves open translation to human hypertension phenotypes.

Structured PICO

Population

Consomic rat strains derived from a cross between the Fawn Hooded Hypertensive rat (FHH/EurMcwi) and the Brown Norway normotensive (BN/NHsdMcwi) rat (male and female)

Intervention

Substitution of individual BN chromosomes into the FHH genetic background, and dietary salt changes (low-salt 0.4% NaCl vs high-salt 4% NaCl for 3 wk)

Comparator

FHH genetic background, different salt diets, and earlier studies of BN x Dahl salt-sensitive (SS) rats

Outcome

Vascular responses of aortic rings to vasoconstrictor (phenylephrine) and vasodilator (acetylcholine, sodium nitroprusside, and reduced tissue bath Po(2)) stimulisurrogate

Genetic factors influencing vascular reactivity in rodent models of hypertension are highly strain- and sex-specific.

Cite This Study

Kunert et al. (2010) studied this question.

synapsesocial.com/papers/6a85134d57526c2f029deffa https://doi.org/10.1152/physiolgenomics.00124.2010

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Vascular reactivity genetics in hypertensive rat models are highly strain- and sex-specific; leaves open translation to human hypertension phenotypes.

Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider