Why the study?
Does a specific minimal intraarterial plasma concentration of fentanyl prevent hypertensive responses to noxious stimuli in patients undergoing aortocoronary bypass surgery?
Does a specific minimal intraarterial plasma concentration of fentanyl prevent hypertensive responses to noxious stimuli in patients undergoing aortocoronary bypass surgery?
A minimal effective plasma concentration of fentanyl to prevent hypertensive responses during aortocoronary bypass surgery could not be established due to high inter-patient variability.
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High interpatient variability precludes a uniform fentanyl target to blunt hypertension; leaves open whether individualized dosing improves outcomes in CABG.
Wynands et al. (1984) studied this question.
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