Why the study?
Does incremental administration of thiopentone compared to bolus administration alter cardiovascular depression in unpremedicated patients?
Population
20 unpremedicated patients (ASA grade I)
Comparison
Thiopentone in 50-mg increments every 15 s until… vs Thiopentone as a 4-mg kg-1 bolus
Design
RCT, assigned randomly
Follow-up
measured every 30 s after administration
Authors
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Incremental thiopentone yields no hemodynamic advantage over bolus despite higher dose; confirms equivalent cardiovascular depression in unpremedicated patients.
Does incremental administration of thiopentone compared to bolus administration alter cardiovascular depression in unpremedicated patients?
Incremental administration of thiopentone requires a higher total dose but produces similar cardiovascular depression compared to a standard bolus dose.
Seltzer et al. (1980) studied this question.
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