Why the study?
Does amlodipine reduce blood pressure safely in hypertensive patients with renal dysfunction?
Does amlodipine reduce blood pressure safely in hypertensive patients with renal dysfunction?
Amlodipine effectively lowers blood pressure without significant drug accumulation or severe aggravation of renal function in hypertensive patients with renal impairment.
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May support amlodipine for BP control in renal impairment; leaves open need for RCT confirmation.
Saruta et al. (1994) studied this question.
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