Why the study?
Does long-term administration of L-NAME alter renal dopaminergic system activity in a nitric oxide-deprived hypertensive rat model?
Population
Nitric oxide-deprived hypertensive rat model
Comparison
Long-term administration of NG-nitro-L-arginine… vs Control rats
Design
Preclinical
Follow-up
14 days
Authors
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Supports compensatory renal dopaminergic adaptation in this rat model; hypothesis-generating, with no implications for human hypertension yet.
Does long-term administration of L-NAME alter renal dopaminergic system activity in a nitric oxide-deprived hypertensive rat model?
In a rat model of nitric oxide-deprived hypertension, long-term L-NAME administration increases renal AAAD activity and urinary excretion of dopamine and 5-hydroxytryptamine, suggesting an adaptational response to decreased nitric oxide generation.
Soares-da-Silva et al. (1995) studied this question.
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