Why the study?
Does the ELISA-based poliovirus-binding inhibition (PoBI) test perform comparably to the virus neutralization test (NT) for detecting and quantifying antibodies to polioviruses?
Does the ELISA-based poliovirus-binding inhibition (PoBI) test perform comparably to the virus neutralization test (NT) for detecting and quantifying antibodies to polioviruses?
The PoBI test is a suitable, high-throughput alternative to the traditional neutralization test for estimating poliovirus seroprevalence in large-scale population studies.
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Supports PoBI for large-scale seroprevalence studies; leaves open prospective validation before replacing NT.
Herremans et al. (1997) studied this question.
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