Population
Commercial poliovaccines from two manufacturers (inactivated poliovirus types 2 and 3) and infectious virus
Comparison
Inactivation process (formalin-inactivated) vs Infectious virus (native virus)
Design
Preclinical
Authors
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May affect interpretation of potency assays for inactivated polio vaccines; hypothesis-generating for effects on human immunity.
Inactivated poliovirus in vaccines differs antigenically from native virus, which may affect in vitro potency assays and the protective immune response in recipients.
Ferguson et al. (1993) studied this question.
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