March 1, 1990Journal of VirologyOpen Access

An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16

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Why the study?

Does a chimeric poliovirus containing HPV-16 sequences induce antibodies against HPV-16 in rabbits?

Population

Rabbits (preclinical model)

Design

Preclinical

Authors

OJOwen JenkinsHealth and Safety Authority JCJ. CasonSTAR Council KBKaren L. BurkeThe Pirbright Institute

Discussion

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Implication

Rabbit data support poliovirus chimeras for HPV antigen delivery; leaves open human immunogenicity and vaccine trials.

Structured PICO

Does a chimeric poliovirus containing HPV-16 sequences induce antibodies against HPV-16 in rabbits?

Population

Rabbits (preclinical model)

Intervention

Chimeric poliovirus containing a 16-residue sequence derived from the major capsid protein (L1) of HPV-16

Outcome

Production of antibodies recognizing the HPV-16-derived peptide, an L1 fusion protein, and HPV-16 in human biopsy materialsurrogate

A chimeric poliovirus expressing HPV-16 antigens successfully induces specific antibodies in a rabbit model, suggesting potential utility as a vaccine vector.

Cite This Study

Jenkins et al. (1990) studied this question.

synapsesocial.com/papers/6a8525a676469a949f43d280 https://doi.org/10.1128/jvi.64.3.1201-1206.1990

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An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider