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February 1, 1965American Journal of Physiology-Legacy Content

Effects of carotid occlusion and left atrial distention on plasma vasopressin titer

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Why the study?

Does left atrial distention inhibit the release of vasopressin induced by carotid occlusion in anesthetized dogs?

Population

Anesthetized dogs (including vagotomized models)

Comparison

Simultaneous inflation of a balloon in the left… vs Occlusion of both common carotid arteries alone

Design

Preclinical

Authors

LSLeonard ShareUniversity of Tennessee Health Science Center

Discussion

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Implication

Left atrial distention blocks carotid-induced ADH release via vagal afferents in dogs; extends volume-sensing mechanisms but leaves open human translation.

Structured PICO

Does left atrial distention inhibit the release of vasopressin induced by carotid occlusion in anesthetized dogs?

P
Population
Anesthetized dogs (including vagotomized models)
I
Intervention
Simultaneous inflation of a balloon in the left atrium during occlusion of both common carotid arteries
C
Comparator
Occlusion of both common carotid arteries alone
O
Outcome
Plasma titer of vasopressin (ADH)surrogate

Activation of stretch receptors in the left atrial wall inhibits ADH release via afferent vagal nerve fibers.

Cite This Study

Leonard Share (1965) studied this question.

synapsesocial.com/papers/6a852ee54edd3eca19cf227ehttps://doi.org/10.1152/ajplegacy.1965.208.2.219
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of Antidiuretic Hormone Due to Common Carotid Occlusion and Its Relation with Vagus Nerve.1962 · 25 citations
  2. 2THE EFFECT OF STIMULATION OF ATRIAL RECEPTORS ON THE PLASMA CONCENTRATION OF VASOPRESSIN1983 · 14 citations
  3. 3Role of Peripheral Receptors in the Increased Release of Vasopressin in Response to Hemorrhage1967 · 52 citations
  4. 4Time course of changes in plasma vasopressin during atrial distension1982 · 22 citations
  5. 5Reflexes elicited by acute stretch of atrial vs. pulmonary receptors in conscious dogs1982 · 29 citations