November 7, 2000Circulation

Deloading of the Left Ventricle by Ventricular Assist Device Normalizes Increased Expression of Endothelin ETA Receptors But Not Endothelin-Converting Enzyme-1 in Patients With End-Stage Heart Failure

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Why the study?

Does ventricular assist device (VAD) unloading normalize the expression of endothelin system components in patients with end-stage heart failure?

Population

Left ventricular myocardium from nonfailing donor hearts, failing hearts without and with ACE inhibitor…

Comparison

Ventricular assist device (VAD) implantation vs Baseline, nonfailing donor hearts, and failing…

Design

Cohort

Follow-up

103+/-15 days

Authors

HMHenning MorawietzUniversity Hospital Carl Gustav Carus MSMarten SziborTampere University Hospital WGWinfried GöettschLeibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Discussion

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Implication

VAD unloading selectively normalizes ETA expression in end-stage HF; hypothesis-generating for differential endothelin effects and requires prospective validation.

Structured PICO

Does ventricular assist device (VAD) unloading normalize the expression of endothelin system components in patients with end-stage heart failure?

Population

Left ventricular myocardium from nonfailing donor hearts, failing hearts without and with ACE inhibitor therapy, and patients with end-stage heart failure at the time of VAD implantation and 103+/-15 days after VAD implantation.

Intervention

Ventricular assist device (VAD) implantation

Comparator

Baseline (at VAD implantation), nonfailing donor hearts, and failing hearts without VAD

Outcome

mRNA expression of components of the endothelin (ET) system (ET(A), ET(B), ET-converting enzyme-1) and ET-1 peptide levelssurrogate

VAD-induced hemodynamic unloading normalizes ET(A) receptor expression in end-stage heart failure, demonstrating a specific molecular reverse-remodeling effect.

Cite This Study

Morawietz et al. (2000) studied this question.

synapsesocial.com/papers/6a853275f2bb7ee68cf23ebd https://doi.org/10.1161/01.cir.102.suppl_3.iii-188

Topics

Mechanical circulatory support Heart failure HFrEF treatment

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Implication

VAD unloading selectively normalizes ETA expression in end-stage HF; hypothesis-generating for differential endothelin effects and requires prospective validation.

Deloading of the Left Ventricle by Ventricular Assist Device Normalizes Increased Expression of Endothelin ETA Receptors But Not Endothelin-Converting Enzyme-1 in Patients With End-Stage Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Deloading of the Left Ventricle by Ventricular Assist Device Normalizes Increased Expression of Endothelin ETA Receptors But Not Endothelin-Converting Enzyme-1 in Patients With End-Stage Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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