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August 13, 2013PLoS ONEOpen Access

The combination therapy significantly suppressed AngII-induced increase in maximal aortic diameter as compared with sham, whereas each monotherapy had no inhibitory effects.

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Why the study?

Does combination therapy with atorvastatin and amlodipine prevent AngII-induced AAA formation in ApoE(-/-) mice?

Population

Apolipoprotein E-deficient (ApoE) mice infused with angiotensin II for 28 days, and human aortic samples.

Comparison

Combination therapy with atorvastatin and… vs Saline infusion alone, AngII infusion alone…

Design

Preclinical, randomly divided

Follow-up

28 days

Authors

KTKikuyo TakahashiYMYasuharu MatsumotoZDZhulanqiqige Do.e

Discussion

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Member takes

Overview

May support combination atorvastatin-amlodipine exploration in murine AAA; leaves open translation to human prevention.

Structured PICO

Does combination therapy with atorvastatin and amlodipine prevent AngII-induced AAA formation in ApoE(-/-) mice?

P
Population
Apolipoprotein E-deficient (ApoE(-/-)) mice infused with angiotensin II (AngII) for 28 days, and human aortic samples (AAA lesion vs control).
I
Intervention
Combination therapy with atorvastatin (10 mg/kg/day) and amlodipine (1 mg/kg/day)
C
Comparator
Saline infusion alone (sham), AngII infusion alone, AngII infusion plus atorvastatin (10 mg/kg/day), and AngII infusion plus amlodipine (1 mg/kg/day)
O
Outcome
Maximal aortic diametersurrogate

Combination therapy with atorvastatin and amlodipine suppresses AngII-induced AAA formation in a mouse model, potentially via Rho-kinase inhibition.

Cite This Study

Takahashi et al. (2013) studied this question.

synapsesocial.com/papers/6a853a67b6c67ec53fcf2907https://doi.org/10.1371/journal.pone.0072558
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Also Consider

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