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September 4, 2009Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Simvastatin markedly reversed AngII-induced AAA formation, neovascularization, ERK phosphorylation, MCP-1 secretion, and MMP activity (which occurred in 95% of AngII-treated mice).

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Why the study?

Does simvastatin prevent angiotensin II-induced abdominal aortic aneurysm formation in ApoE(-/-) mice?

Population

Apolipoprotein E-knockout mice infused with angiotensin II via osmotic minipumps, and human umbilical vein…

Comparison

Simvastatin or ERK inhibitor CI1040 for 28 days… vs Placebo

Design

Preclinical

Follow-up

28 days

Authors

YZYali ZhangJNJack NaggarCWCharles M. Welzig

Discussion

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Overview

Simvastatin attenuates AAA in ApoE-/- mice; leaves open translation to human prevention and does not support clinical use.

Structured PICO

Does simvastatin prevent angiotensin II-induced abdominal aortic aneurysm formation in ApoE(-/-) mice?

P
Population
Apolipoprotein E-knockout (ApoE-/-) mice infused with angiotensin II (AngII) via osmotic minipumps, and human umbilical vein endothelial cells (HUVECs).
I
Intervention
Simvastatin (10 mg/kg/d) or ERK inhibitor CI1040 (100 mg/kg/d) for 28 days in mice; simvastatin and ERK inhibitor U0126 in HUVECs.
C
Comparator
Placebo
O
Outcome
Abdominal aortic aneurysm (AAA) formation and associated neovascularization, ERK phosphorylation, MCP-1 secretion, and MMP activity.surrogate

Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in ApoE(-/-) mice, likely via ERK inhibition.

Cite This Study

Zhang et al. (2009) studied this question.

synapsesocial.com/papers/6a8cf952286a877edd968245https://doi.org/10.1161/atvbaha.109.192609
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibitory Effect of Statins on Inflammation-Related Pathways in Human Abdominal Aortic Aneurysm Tissue2015 · 62 citations
  2. 2Combination Therapy with Atorvastatin and Amlodipine Suppresses Angiotensin II-Induced Aortic Aneurysm Formation2013 · 28 citations
  3. 3Angiotensin‐(1‐7) mitigated angiotensin II‐induced abdominal aortic aneurysms in apolipoprotein E‐knockout mice2019 · 34 citations
  4. 4Efficacy and Mechanism of Angiotensin II Receptor Blocker Treatment in Experimental Abdominal Aortic Aneurysms2012 · 79 citations
  5. 5Cilostazol Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E–Deficient Mice2018 · 59 citations