Why the study?
Does chronic sinoaortic denervation alter plasma catecholamines and adrenoceptors in dogs?
Population
Conscious dogs
Comparison
Chronic sinoaortic denervation performed by… vs Baseline values before SAD
Design
Preclinical
Follow-up
8 months
Authors
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Transient beta2 but sustained alpha2 adrenoceptor changes after SAD in dogs; leaves open translation to human sympathetic regulation in hypertension.
Does chronic sinoaortic denervation alter plasma catecholamines and adrenoceptors in dogs?
The development of SAD-induced hypertension in dogs is associated with a transient increase in sympathetic tone, with leukocyte beta 2 adrenoceptors directly regulated by endogenous catecholamine levels.
Valet et al. (1989) studied this question.
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