Specificity of H ion concentration as a carotid chemoreceptor stimulus

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Population

Cats (preclinical model)

Design

Preclinical

Authors

Discussion

Should not yet inform human chemoreflex therapies; leaves open species-specific CO2 sensing in translational models.

Population

Cats (preclinical model)

Intervention

Combination of respiratory and metabolic acidosis or alkalosis to separate effects of (H+) and Pco2

Outcome

Integrated electrical activity from the entire Hering's nervesurrogate

This preclinical study demonstrates that hydrogen ion concentration, rather than Pco2, is the primary stimulus for carotid chemoreceptors.

Hornbein et al. (1963) studied this question.

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