December 5, 2007Clinical Infectious Diseases
Antiviral Therapy and Outcomes of Influenza Requiring Hospitalization in Ontario, Canada
Why the study?
Does antiviral therapy reduce mortality in patients hospitalized with influenza?
Population
512 patients hospitalized with laboratory-confirmed influenza. Adult median age 77, 51% male, 75% with…
Comparison
Antiviral drugs active against influenza vs No antiviral therapy
Design
Cohort
Follow-up
15 days after symptom onset
Authors
Discussion
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Member takes
Implication
May support antiviral use in hospitalized influenza; leaves open need for RCTs to confirm mortality benefit.
Structured PICO
Does antiviral therapy reduce mortality in patients hospitalized with influenza?
P
Population
512 patients (185 children <15 years, 327 adults) hospitalized with laboratory-confirmed influenza. Adult median age 77, 51% male, 75% with chronic underlying illness, 71% vaccinated against influenza.
I
Intervention
Antiviral drugs active against influenza
C
Comparator
No antiviral therapy
O
Outcome
Death within 15 days after symptom onsethard clinical
Antiviral therapy is associated with significantly reduced mortality in adults hospitalized with influenza.
Cite This Study
McGeer et al. (2007) studied this question.