What question did this study set out to answer?

To quantify catecholamine concentrations in distinct arterial and venous segments of the canine foreleg and determine their relationship with neural responsiveness and pharmacological challenge.

November 1, 1968Circulation ResearchOpen Access

Catecholamines in Arteries and Veins of the Foreleg of the Dog

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To quantify catecholamine concentrations in distinct arterial and venous segments of the canine foreleg and determine their relationship with neural responsiveness and pharmacological challenge.
Measured catecholamine concentrations across vascular segments using a fluorimetric method (48 segments from 11 dogs) and a bioassay (33 segments from 8 dogs).
Evaluated vascular catecholamine content following reserpine pretreatment and after intravenous infusion of norepinephrine that raised circulating levels five- to tenfold.
Fluorimetric analysis showed lower catecholamine concentrations in the brachial artery (0.14 µg/g wet tissue) versus ulnar (0.70 µg/g) and metacarpal arteries (0.66 µg/g), and in the brachial vein (0.17 µg/g) versus cephalic (1.30 µg/g) and metacarpal veins (0.47 µg/g).
Vascular catecholamine concentrations correlated closely with the known responsiveness of specific vessel segments to nerve stimulation.
Pretreatment with reserpine markedly depleted catecholamines in the ulnar artery and cephalic vein, while systemic norepinephrine infusion produced no change in ulnar artery content.

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Implication

Experimental study reveals regional variations in vascular catecholamines in canine forelegs, suggesting direct correlation with neural responsiveness.

Cite This Study

Mayer et al. (1968) studied this question.

synapsesocial.com/papers/6a854d3cd1e5e0588dd4c67d https://doi.org/10.1161/01.res.23.5.653

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Implication

Experimental study reveals regional variations in vascular catecholamines in canine forelegs, suggesting direct correlation with neural responsiveness.

Catecholamines in Arteries and Veins of the Foreleg of the Dog

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Catecholamines in Arteries and Veins of the Foreleg of the Dog

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