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November 1, 1919The Journal of Nervous and Mental DiseaseOpen Access

Neutralization of Virus of Poliomyelitis by Nasal Washings

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Why the study?

Do nasal and pharyngeal washings possess the power to inactivate or neutralize the active virus of poliomyelitis?

Population

Nasal and pharyngeal washings from humans (adults and children, including some with poliomyelitis)

Design

Preclinical

Authors

HAHarold L. AmossUniversity of WashingtonETEdward A. TaylorFlorida Department of Citrus

Discussion

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Implication

Mucosal neutralization of poliomyelitis virus suggested in animals; leaves open human defense or carrier implications.

Structured PICO

Do nasal and pharyngeal washings possess the power to inactivate or neutralize the active virus of poliomyelitis?

P
Population
Nasal and pharyngeal washings from humans (adults and children, including some with poliomyelitis)
I
Intervention
Exposure of poliomyelitis virus to nasal and pharyngeal washings
O
Outcome
Inactivation or neutralization of the active virus of poliomyelitissurrogate

Nasal and pharyngeal washings contain a water-soluble, thermolabile substance capable of neutralizing the poliomyelitis virus, which may play a role in defense against infection or the production of healthy carriers.

Limitations

  • Too few tests have been made thus far to ascertain whether adults and children differ with respect to the existence of this neutralizing property

Cite This Study

Amoss et al. (1919) studied this question.

synapsesocial.com/papers/6a8567c6734852141cd4cdd7https://doi.org/10.1097/00005053-191911000-00051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NEUTRALIZATION OF THE VIRUS OF POLIOMYELITIS BY NASAL WASHINGS1917 · 32 citations
  2. 2THE NEUTRALIZATION TEST IN POLIOMYELITIS1935 · 26 citations
  3. 3Experimental Poliomyelitis. Active Immunization with Neutralized Mixtures of Virus and Serum.1933 · 3 citations
  4. 4SURVIVAL OF THE VIRUS OF POLIOMYELITIS IN THE ORAL AND NASAL SECRETION OF CONVALESCENTS1936 · 12 citations
  5. 5On the Property of Certain Normal Animal Sera to Neutralize the Virus of Poliomyelitis.1932 · 6 citations