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August 1, 1936The Journal of Experimental MedicineOpen Access

Survival of the Virus of Poliomyelitis in the Oral and Nasal Secretion of Convalescents

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Population

2 children convalescing from poliomyelitis and 7 animals inoculated with concentrated nasal secretions

Design

Preclinical

Follow-up

Up to 43 days after onset of illness

Authors

SKStefanie D. KrämerETH ZurichASAlbert E. SobelJewish HospitalLGLauren GrossmanIntegrative Medicine Institute

Discussion

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Implication

Virus detection up to 43 days may extend isolation considerations; leaves open confirmation of human transmissibility.

Structured PICO

P
Population
2 children convalescing from poliomyelitis and 7 animals inoculated with concentrated nasal secretions
I
Intervention
Inoculation with concentrated nasal secretions
O
Outcome
Detection of poliomyelitis virus and development of symptoms/histologic findings in inoculated animalssurrogate

The detection of poliomyelitis virus in nasal secretions up to 43 days post-onset supports the adequacy of a 3-week quarantine period.

Cite This Study

Krämer et al. (1936) studied this question.

synapsesocial.com/papers/6a735307ef143ecf1cf12e75https://doi.org/10.1084/jem.64.2.173
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DETECTION OF THE VIRUS OF POLIOMYELITIS IN THE NOSE AND THROAT AND GASTRO-INTESTINAL TRACT OF HUMAN BEINGS AND MONKEYS1939 · 44 citations
  2. 2PERSISTENCE OF THE VIRUS OF POLIOMYELITIS IN THE NASOPHARYNX1919 · 13 citations
  3. 3ISOLATION OF POLIOMYELITIS VIRUS FROM THE NASOPHARYNX1935 · 25 citations
  4. 4RAPID DEVELOPMENT OF CARRIER STATE AND DETECTION OF POLIOMYELITIS VIRUS1945 · 16 citations
  5. 5STUDIES ON ENTRY AND EGRESS OF POLIOMYELITIC INFECTION1951 · 7 citations