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November 1, 1917The Journal of Experimental MedicineOpen Access

Carriage of the Virus of Poliomyelitis, With Subsequent Development of the Infection

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Key result

In a family of four children with poliomyelitis, two were proven to carry the virus in the nasopharynx, suggesting that every case develops from a carrier of the virus.

Population

A family group containing four children showing varying degrees of poliomyelitis symptoms.

Design

Case_series

Follow-up

1 month

Authors

ETEdward A. TaylorFlorida Department of CitrusHAHarold L. AmossUniversity of Washington

Discussion

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Implication

May support nasopharyngeal carriage in poliomyelitis families; leaves open whether all cases arise from carriers and requires larger studies.

Study Design

Type

Case Report (n=4)

Structured PICO

P
Population
4 children from a single family group who showed varying degrees of poliomyelitis symptoms.
E
Exposure
Immune serum (administered to the youngest child)
O
Outcome
Presence of poliomyelitis virus in the nasopharynx and clinical recovery

The study demonstrates that individuals can be asymptomatic carriers of the poliomyelitis virus before or after clinical symptoms.

Cite This Study

Taylor et al. (1917) conducted a case report in Poliomyelitis (n=4). Poliomyelitis virus carriage was evaluated on Development of poliomyelitis infection and carrier status. In a family of four children with poliomyelitis, two were proven to carry the virus in the nasopharynx, suggesting that every case develops from a carrier of the virus.

synapsesocial.com/papers/6a92b17c030f5598b797a23chttps://doi.org/10.1084/jem.26.5.745
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RAPID DEVELOPMENT OF CARRIER STATE AND DETECTION OF POLIOMYELITIS VIRUS1945 · 16 citations
  2. 2PERSISTENCE OF THE VIRUS OF POLIOMYELITIS IN THE NASOPHARYNX1919 · 13 citations
  3. 3STUDIES OF THE DISTRIBUTION OF POLIOMYELITIS VIRUS1948 · 24 citations
  4. 4SURVIVAL OF THE VIRUS OF POLIOMYELITIS IN THE ORAL AND NASAL SECRETION OF CONVALESCENTS1936 · 12 citations
  5. 5Detection of a Healthy Carrier of Virus of Poliomyelitis Without History of Contact.1935 · 11 citations