Key result
Addition of non-infectious poliomyelitis virus activated poliomyelitis virus from a neutral virus-antibody mixture in a type-specific manner, correlating with protection-inducing activity in mice.
Population
Tissue cultures (Petri dishes and roller tubes) and mice
Design
Preclinical
Authors
Loading...
May enable in vitro potency testing of poliovirus antigens; leaves open translation beyond mouse models.
The antigenic potency of non-infectious poliomyelitis virus can be determined in tissue culture by its ability to liberate active virus from a neutral virus-antibody mixture, correlating with in vivo protection in mice.
U. Krech (1955) studied Poliomyelitis. Non-infectious poliomyelitis virus was evaluated on Activation of poliomyelitis virus from a neutral virus-antibody mixture. Addition of non-infectious poliomyelitis virus activated poliomyelitis virus from a neutral virus-antibody mixture in a type-specific manner, correlating with protection-inducing activity in mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: