February 13, 2002Human Mutation

Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension

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Why the study?

Are ALAP gene polymorphisms associated with essential hypertension in Japanese individuals?

Population

635 Japanese individuals

Comparison

Presence of ALAP gene missense polymorphisms vs Absence of the polymorphism

Design

Case-control

Authors

NYNao YamamotoShinko Hospital JNJunko NakayamaIbaraki Prefectural University of Health Sciences KYKimiko Yamakawa‐KobayashiUniversity of Shizuoka

Discussion

Member takes

Implication

Association warrants no practice change; leaves open ALAP role in hypertension risk among Japanese.

Structured PICO

Are ALAP gene polymorphisms associated with essential hypertension in Japanese individuals?

Population

635 Japanese individuals (48 unrelated individuals for initial screening, 96 apparently healthy individuals for stage 1, and 143 hypertensive and 348 normotensive subjects for stage 2)

Intervention

Presence of ALAP gene missense polymorphisms (specifically the Arg allele at codon 528)

Comparator

Absence of the polymorphism (Lys/Lys genotype at codon 528)

Outcome

Essential hypertension and individual variations in blood pressuresurrogate

The Lys528Arg polymorphism in the ALAP gene is significantly associated with essential hypertension in Japanese individuals, suggesting a genetic role in blood pressure regulation.

Cite This Study

Yamamoto et al. (2002) studied this question.

synapsesocial.com/papers/6a857cc4581d4f62e2d5a44d https://doi.org/10.1002/humu.10047

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider