Why the study?
Does captopril improve blood pressure control in patients with refractory severe hypertension of renal origin?
Does captopril improve blood pressure control in patients with refractory severe hypertension of renal origin?
Captopril is effective in controlling refractory severe hypertension of renal origin, though it carries risks of hyperkalemia and other adverse effects.
Answers are grounded in this paper and cite their sources.
May support captopril in refractory renal hypertension; leaves open efficacy, dosing, and safety in larger studies.
The converting-enzyme inhibitor, captopril, was given to ten patients with refractory severe hypertension of renal origin: 6 patients had chronic renal failure, 3 patients had hypertension following renal transplantation, and one patient had hypertension and congestive cardiac failure. Control of blood pressure was achieved with doses from 78 to 400 mg/day. Severe hyperkalaemia occurred in one patients, ageusia (dose dependent) in another, and one patients withdrew from treatment because of nausea.
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Hamilton et al. (1981) studied this question.
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