Further Observations on the State of the Catechol Amines Stored in the Adrenal Medullary Granules

On incubation of amine granules from cow adrenal medulla in media containing labelled adrenaline no significant exchange between this adrenaline and the amines stored in the granules was found. This and other findings indicate that the stored amines are bound in a non‐diffusible state in combination with adenosinephos‐phates and probably with intragranular proteins. The supposed complex binding the amines seems to be a very labile structure, which is destroyed on disruption of the granule membrane.