Population
Single isolated guinea-pig ventricular myocytes
Comparison
Calcium overload induced by removal of Ca2+ and… vs Less severe Ca2+ overload or baseline Tyrode…
Design
Preclinical
Authors
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Hypothesis-generating for Ca2+-driven mitochondrial failure in myocytes; leaves open translation to human HF or ischemia.
Calcium overload in ventricular myocytes leads to energy depletion via failure of the citric acid cycle to provide sufficient NADH and uncoupling of respiration due to mitochondrial depolarization.
Minezaki et al. (1994) studied this question.
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