Key result
Pretreatment with the calcineurin inhibitors Cyclosporin A or FK506 protected against LPS-induced systolic and diastolic myocardial dysfunction and normalized mitochondrial respiratory function.
Why the study?
Does calcineurin inhibition with cyclosporin A or tacrolimus preserve left ventricular function and mitochondrial respiration in a cat model of acute endotoxemia?
Does calcineurin inhibition with cyclosporin A or tacrolimus preserve left ventricular function and mitochondrial respiration in a cat model of acute endotoxemia?
p-value: p=<0.01
Calcineurin inhibition with cyclosporin A or tacrolimus preserves cardiac contractile function and mitochondrial respiration during acute endotoxemia in a feline model, indicating calcineurin is a critical regulator of these processes.
Calcineurin inhibition merits investigation in sepsis cardiomyopathy; leaves open translation from feline endotoxemia model.
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Joshi et al. (2006) studied Acute Endotoxemia (Sepsis) (n=29). Cyclosporin A (CsA) or Tacrolimus (FK506) vs. LPS alone (3 mg/kg) or saline control was evaluated on Left ventricular contractility (maximum dP/dT) and mitochondrial respiratory function (p=<0.01). Pretreatment with the calcineurin inhibitors Cyclosporin A or FK506 protected against LPS-induced systolic and diastolic myocardial dysfunction and normalized mitochondrial respiratory function.
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