Population
Paced fura 2-loaded myocytes isolated from Sham, renovascular hypertensive, and myocardial-infarcted rats
Comparison
1 microM isoproterenol vs Sham myocytes and baseline conditions without…
Design
Preclinical
Authors
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May explain beta-blocker inefficacy in hypertensive HCM diastolic dysfunction; hypothesis-generating for MI-specific Ca2+ handling.
The observation that isoproterenol lowers diastolic [Ca2+]i in hypertensive myocytes toward normal provides a potential cellular mechanism for the lack of efficacy of beta-blockers in improving diastolic compliance in hypertensive hypertrophic cardiomyopathy.
Zhang et al. (1995) studied this question.
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