Key result
In atherosclerotic plaques, tissue levels of TNF-alpha and ICAM-1 were negatively correlated with adiponectin and positively correlated with blood glucose, smoking, and diabetes.
Observational (n=37)
Diabetic state and smoking are associated with altered levels of inflammatory cytokines and adiponectin in coronary atherosclerotic plaques, supporting a chronic inflammatory mechanism in atherosclerosis.
Diabetic state and smoking may promote plaque inflammation via adiponectin; hypothesis-generating and should not yet change practice.
BACKGROUND: There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM: To analyse tissue levels of adiponectin, ICAM-1, TNF-alpha and H-FABP in the plaques obtained from coronary artery bypass grafting (CABG) and to evaluate whether there is any relationship between these variables and other characteristics. PATIENTS AND METHODS: Coronary artery specimens from 37 consecutive patients (28 men and nine women) at time of CABG procedure and preprocedural blood samples were obtained. Tissue concentrations of adiponectin, ICAM-1, TNF-alpha and H-FABP in the atherosclerotic plaques were measured. RESULTS: Blood glucose and tissue levels of TNF-alpha and ICAM-1 were negatively correlated with tissue levels of adiponectin, whereas TNF-alpha was positively correlated with ICAM-1 in atherosclerotic plaques. In addition, there was a positive correlation between blood glucose and tissue levels of both TNF-alpha and ICAM-1. TNF-alpha and ICAM-1 levels in atherosclerotic plaques appear to progressively increase whereas adiponectin levels progressively decrease with smoking status. Atherosclerotic tissue levels of these substances are also altered in diabetes. CONCLUSIONS: The data are in accord with those in prior publications on the detection and quantification of various inflammatory cytokines in atherosclerotic plaques. Our results indicate that diabetic state and smoking, in addition to other physiopathological mechanisms, may create a chronic inflammatory situation in the atherosclerotic process.
No takes yet. Share an insight, caveat, or question.
Karaduman et al. (2006) conducted an observational in Coronary atherosclerosis (n=37). Clinical characteristics (blood glucose, smoking, diabetes) was evaluated on Correlations between tissue levels of adiponectin, ICAM-1, TNF-alpha, H-FABP and clinical characteristics. In atherosclerotic plaques, tissue levels of TNF-alpha and ICAM-1 were negatively correlated with adiponectin and positively correlated with blood glucose, smoking, and diabetes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: