May 15, 1996The Journal of PhysiologyOpen Access

Contribution of a non‐inactivating potassium current to the resting membrane potential of fusion‐competent human myoblasts.

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Population

Cultured fusion-competent human myoblasts

Design

Preclinical

Authors

LBLaurent BernheimUniversity of Geneva JLJian-Hui LiuHôpital Nestlé MHMartine HamannUniversity of Leicester

Discussion

Member takes

Implication

Hypothesis-generating for myoblast fusion in regeneration; leaves open translational relevance to human cardiac repair.

Structured PICO

Population

Cultured fusion-competent human myoblasts

Intervention

Electrophysiological characterization using patch-clamp technique and pharmacological agents (charybdotoxin, dendrotoxins, MCD peptide, 4-AP, 3,4-DAP, apamin, TEA, Ba2+)

Outcome

Characterization of the non-inactivating voltage-gated potassium current (IK(ni)) and its contribution to resting membrane potentialsurrogate

A novel non-inactivating potassium current, IK(ni), regulates the resting membrane potential of human myoblasts and may play a key role in myoblast fusion.

Cite This Study

Bernheim et al. (1996) studied this question.

synapsesocial.com/papers/6a8596da916c5a6accadb785 https://doi.org/10.1113/jphysiol.1996.sp021369

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Contribution of a non‐inactivating potassium current to the resting membrane potential of fusion‐competent human myoblasts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of a non‐inactivating potassium current to the resting membrane potential of fusion‐competent human myoblasts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider