Why the study?
Does sildenafil improve pulmonary hypertension in patients with advanced heart failure?
Does sildenafil improve pulmonary hypertension in patients with advanced heart failure?
Sildenafil shows potential as a treatment for pulmonary hypertension in advanced heart failure, warranting further investigation.
Pulmonary hypertension is a daunting accompaniment of advanced heart failure. Efforts to safely and consistently lower pulmonary vascular resistance are necessary but fraught with challenges. In this report the authors explore the novel use of sildenafil, an inhibitor of phosphodiesterase-5, in tackling pulmonary hypertension in heart failure. The salutary effects of this agent deserve further study.
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Alaeddini et al. (2003) studied this question.
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