Key result
An ultra-performance LC-MS/MS method was successfully developed and validated for quantifying clopidogrel active metabolite in human plasma with a lower LOQ of 0.8 ng/mL and 5-minute analysis time.
A rapid, 5-minute LC-MS/MS method was successfully developed and validated for the quantification of clopidogrel active metabolite in human plasma.
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Enables rapid clopidogrel metabolite quantification in research; leaves open clinical monitoring applications pending validation.
Delavenne et al. (2010) studied Healthy volunteers. Clopidogrel was evaluated on Quantification of clopidogrel active metabolite (method validation parameters). An ultra-performance LC-MS/MS method was successfully developed and validated for quantifying clopidogrel active metabolite in human plasma with a lower LOQ of 0.8 ng/mL and 5-minute analysis time.
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