Key result
A sensitive and fast UHPLC-MS/MS method was developed for simultaneous quantitation of clopidogrel and its metabolites in human plasma, achieving an LLOQ of 0.05 ng/ml.
Population
Human plasma
Design
Other
Authors
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May facilitate clopidogrel pharmacokinetic studies; leaves open clinical adoption pending validation.
This study presents a highly sensitive and fast UHPLC-MS/MS method for quantifying clopidogrel and its active metabolite H4 in human plasma, which could facilitate pharmacokinetic studies.
Hua et al. (2015) studied this question. UHPLC-MS/MS method was evaluated on Simultaneous quantitation of clopidogrel, clopidogrel acid and active metabolite H4. A sensitive and fast UHPLC-MS/MS method was developed for simultaneous quantitation of clopidogrel and its metabolites in human plasma, achieving an LLOQ of 0.05 ng/ml.
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