Why the study?
Does the combination of atenolol and hydrochlorothiazide/triamterene improve antihypertensive effects compared to monotherapy or placebo in patients with mild-to-moderate essential hypertension?
Population
256 patients with mild-to-moderate essential-hypertension
Comparison
Atenolol combined with a fixed combination of… vs Placebo, hydrochlorothiazide/triamterene alone…
Design
RCT, Randomized to 6 groups: PL, HCTZ/TRI, Ate-25, Ate-50, Ate-25/HCTZ/TRI…
Follow-up
4 weeks (up to 16 weeks for combination groups)
Authors
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Supports atenolol-HCTZ/triamterene combinations for greater BP reduction in mild hypertension; confirms additive effects of beta-blocker-diuretic regimens.
Does the combination of atenolol and hydrochlorothiazide/triamterene improve antihypertensive effects compared to monotherapy or placebo in patients with mild-to-moderate essential hypertension?
Combining atenolol with hydrochlorothiazide and triamterene provides greater blood pressure reduction than monotherapy but is associated with mild metabolic disturbances.
Chrysant et al. (1992) studied this question.
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