Why the study?
What is the quantitative relationship between angiotensin converting enzyme activity in human serum and the concentration of the MK-421 active diacid metabolite in vitro and in vivo?
Population
Human serum (in vitro) and serum from hypertensive subjects (in vivo)
Design
Other
Authors
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Potent in vitro ACE inhibition by MK-421 diacid supports further development; chronic effects and clinical translation remain uncertain.
What is the quantitative relationship between angiotensin converting enzyme activity in human serum and the concentration of the MK-421 active diacid metabolite in vitro and in vivo?
The active diacid metabolite of MK-421 demonstrates potent inhibition of serum angiotensin converting enzyme activity with similar dose-response characteristics in vitro and after single in vivo doses.
Swanson et al. (1982) studied this question.
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