Why the study?
Do MK 421 and its lysine analogue inhibit angiotensin converting enzyme and alter the renin-angiotensin-aldosterone system in healthy normotensive volunteers?
Population
12 normotensive healthy volunteers
Design
Cohort
Follow-up
72 hours
Authors
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Prolonged ACE suppression in volunteers supports early development of MK 421; leaves clinical translation in patients open.
Do MK 421 and its lysine analogue inhibit angiotensin converting enzyme and alter the renin-angiotensin-aldosterone system in healthy normotensive volunteers?
MK 421 and its lysine analogue are effective, long-acting ACE inhibitors that significantly suppress plasma converting enzyme activity and alter the renin-angiotensin-aldosterone system in healthy volunteers.
Brunner et al. (1981) studied this question.
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