January 1, 1982Endocrinologia JaponicaOpen Access

Effects of a new angiotensin-converting enzyme inhibitor, MK 421, in normal men and patients.

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Why the study?

Does MK 421 lower blood pressure and alter renin-angiotensin-aldosterone system hormones in normal men and hypertensive patients?

Population

9 subjects

Design

Case_series

Follow-up

up to 24 hours and 2 to 6 months

Authors

TKTsuyoshi KonoSt. Marianna University School of Medicine FOFumimaro OsekoKyoto University FIFumitake IkedaKyoto University

Discussion

Member takes

Implication

May warrant further study of MK 421 in hypertension; leaves open efficacy and safety in controlled trials.

Structured PICO

Does MK 421 lower blood pressure and alter renin-angiotensin-aldosterone system hormones in normal men and hypertensive patients?

Population

9 subjects (5 normal men, 2 patients with essential hypertension, 1 patient with Bartter's syndrome, 1 patient with malignant hypertension)

Intervention

MK 421 (ACE inhibitor) given as a single oral dose (10-20 mg) and/or daily doses of 5-40 mg for 2-6 months

Outcome

Blood pressure and plasma hormone levels (angiotensin I, renin activity, aldosterone)surrogate

MK 421 is a strong, long-acting ACE inhibitor that effectively lowers blood pressure and modulates the renin-angiotensin-aldosterone system.

Cite This Study

Kono et al. (1982) studied this question.

synapsesocial.com/papers/6a8a3e8a1c70e695d8435625 https://doi.org/10.1507/endocrj1954.29.615

Topics

Hypertension management

View Full Paper

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Bookmark

Effects of a new angiotensin-converting enzyme inhibitor, MK 421, in normal men and patients.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of a new angiotensin-converting enzyme inhibitor, MK 421, in normal men and patients.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider