Why the study?
Does enalapril lower blood pressure and alter humoral and renal parameters in hospitalized hypertensive patients?
Population
6 hospitalized hypertensive patients receiving constant sodium intake
Comparison
Enalapril in single daily doses, starting with… vs Placebo run-in (baseline comparison)
Design
Case_series
Authors
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Single-case observation supports dose-dependent enalapril effects; leaves open need for randomized confirmation before practice change.
Does enalapril lower blood pressure and alter humoral and renal parameters in hospitalized hypertensive patients?
Enalapril effectively lowers blood pressure in hypertensive patients through ACE inhibition, accompanied by sodium loss and decreased sympathetic activity.
Leeuw et al. (1983) studied this question.
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