Key result
Point-of-care H-FABP testing combined with clinical signs and symptoms will be evaluated in a planned diagnostic study to determine its accuracy in ruling out acute coronary syndrome in primary care.
Why the study?
Does a diagnostic algorithm combining signs, symptoms, and point-of-care H-FABP testing improve the triage of patients with suspected acute coronary syndrome in primary care?
Population
600 planned patients presenting to a general practitioner with new-onset chest pain or pressure, upper arm…
Comparison
Diagnostic algorithm combining clinical signs… vs Regular clinical assessment by a general…
Design
Cross-sectional, Expert panel adjudicating final diagnosis blinded to PoC…
Follow-up
30 days
Authors
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Should not yet alter primary care ACS triage; leaves open the added diagnostic value of combined H-FABP testing pending planned study.
Does a diagnostic algorithm combining signs, symptoms, and point-of-care H-FABP testing improve the triage of patients with suspected acute coronary syndrome in primary care?
This study protocol describes a planned diagnostic study to determine if point-of-care H-FABP testing combined with clinical assessment can safely rule out acute coronary syndrome in primary care.
Willemsen et al. (2014) studied Chest complaints possibly matching acute coronary syndrome (ACS) (n=600). Point-of-care H-FABP testing combined with signs and symptoms vs. Regular assessment by a GP without PoC H-FABP testing was evaluated on Sensitivity, specificity, positive and negative predictive value of an algorithm of relevant signs and symptoms combined with PoC H-FABP testing for ACS and AMI. Point-of-care H-FABP testing combined with clinical signs and symptoms will be evaluated in a planned diagnostic study to determine its accuracy in ruling out acute coronary syndrome in primary care.
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