Key result
In patients presenting with chest pain, H-FABP (cut-off 4.0 ng/ml) had a sensitivity of 73.9% for ACS, compared to 70.6% for hs-cTnT, with an AUC of 0.79 versus 0.80.
Why the study?
Does point-of-care H-FABP testing accurately diagnose acute coronary syndrome compared to hs-cTnT in patients presenting with new-onset chest complaints?
Observational (n=202)
Does point-of-care H-FABP testing accurately diagnose acute coronary syndrome compared to hs-cTnT in patients presenting with new-onset chest complaints?
Absolute Event Rate: 73.9% vs 70.6%
H-FABP at a cut-off of 4.0 ng/ml shows comparable diagnostic accuracy to hs-cTnT for acute coronary syndrome in emergency department patients with chest pain.
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Comparable accuracy does not support replacing hs-cTnT; leaves open adjunctive value pending prospective validation.
Willemsen et al. (2015) conducted an observational in suspected acute coronary syndrome (n=202). H-FABP test vs. hs-cTnT test was evaluated on Sensitivity for acute coronary syndrome. In patients presenting with chest pain, H-FABP (cut-off 4.0 ng/ml) had a sensitivity of 73.9% for ACS, compared to 70.6% for hs-cTnT, with an AUC of 0.79 versus 0.80.
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